Crashing Fatigue & Energy Depletion
Sudden, overwhelming exhaustion that feels like hitting a wall—distinct from normal tiredness, often unrelieved by rest, and linked to hormonal shifts, sleep disruption, and metabolic changes.
Systems involved
Contributing factors
What It Is
Crashing fatigue is not regular tiredness. It's a profound, body-deep exhaustion that feels like:
- "I can barely lift my head"
- "I need to lie down right now"
- "My body is made of lead"
- "I'm running on fumes"
It can hit suddenly (the "crash"), or it can be a constant baseline of depletion. It's unrelieved by sleep, caffeine, or willpower. It affects every aspect of life—work, relationships, self-care, joy.
60-70% of perimenopausal women report significant fatigue. It's one of the most debilitating symptoms, yet often dismissed as "just stress" or "normal aging."
Why It Happens
Fatigue in perimenopause is multi-factorial:
1. Sleep Deprivation
- Night sweats wake you repeatedly
- Fragmented sleep prevents deep, restorative sleep
- Anxiety makes it hard to fall or stay asleep
- Cumulative sleep debt over months or years
Sleep deprivation alone can cause profound fatigue, brain fog, mood changes, and physical exhaustion.
2. Hormonal Disruption
Estrogen's role in energy:
- Supports mitochondrial function (cellular energy production)
- Regulates glucose metabolism (energy from food)
- Affects neurotransmitters (dopamine, serotonin) that influence motivation and energy
- Supports thyroid function
When estrogen fluctuates or declines:
- Energy production at the cellular level is impaired
- Glucose regulation becomes less efficient
- Motivation and drive can plummet
- Thyroid function may be affected
Progesterone:
- Low progesterone can disrupt sleep (worsening fatigue)
- Affects GABA receptors (calmness and restorative rest)
3. Adrenal and Cortisol Dysregulation
Chronic stress + poor sleep + hormonal changes = adrenal strain:
- Cortisol (stress hormone) can become dysregulated
- High cortisol at night (interferes with sleep)
- Low cortisol in the morning (hard to wake up, no energy)
- "Wired and tired" pattern: anxious but exhausted
4. Thyroid Dysfunction
Hypothyroidism (underactive thyroid) is common in perimenopause:
- Causes profound fatigue, weight gain, brain fog, cold intolerance
- Often overlooked or misdiagnosed
- Requires blood test (TSH, free T4, free T3)
5. Anemia
Heavy or irregular periods (common in perimenopause) can cause iron-deficiency anemia:
- Low iron = low oxygen delivery to tissues = exhaustion
- Also causes shortness of breath, dizziness, pale skin
6. Metabolic Shifts
Perimenopause changes metabolism:
- Insulin sensitivity decreases
- Blood sugar regulation becomes less stable
- Energy "crashes" after meals or when skipping meals
7. Emotional and Mental Load
Managing intense physical symptoms, life stress, caregiving, and work demands while exhausted creates a massive cognitive and emotional burden that depletes energy further.
Common Experiences
Types of Fatigue
Constant baseline exhaustion:
- Wake up tired, stay tired all day
- No amount of rest helps
- Feel like you're moving through molasses
Sudden crashes:
- Sudden wave of overwhelming fatigue
- Need to lie down immediately
- Can happen mid-day, after meals, or without warning
Post-exertional fatigue:
- Disproportionate exhaustion after minimal activity
- Exercise that used to energize now depletes for days
- "Payback" after any exertion
Wired and tired:
- Exhausted but can't sleep
- Anxious, jittery, but no energy
- Cortisol dysregulation
Impact on Daily Life
Work:
- Difficulty concentrating, completing tasks
- Calling in sick more often
- Fear of job loss or poor performance reviews
Relationships:
- Too tired for social activities, sex, quality time
- Irritability and short temper
- Guilt and shame for not being "present"
Self-care:
- Too tired to exercise, cook healthy meals, shower
- Survival mode: doing the bare minimum
Joy and purpose:
- No energy for hobbies, passions, creativity
- Life feels like just "getting through the day"
What Helps
1. Address Sleep First
Sleep is the foundation. If you're not sleeping, nothing else will fully work.
- Treat night sweats (estrogen, gabapentin, cooling strategies)
- Improve sleep hygiene (cool room, dark, consistent schedule)
- Consider magnesium, melatonin (if appropriate)
- Treat anxiety or racing thoughts (therapy, medication if needed)
2. Test for Underlying Causes
Essential labs:
- Thyroid: TSH, free T4, free T3 (hypothyroidism is common)
- Iron: Ferritin, iron, total iron-binding capacity (anemia)
- Vitamin B12: Deficiency causes fatigue, brain fog
- Vitamin D: Deficiency worsens fatigue, mood
- Cortisol: AM cortisol or 4-point salivary cortisol (adrenal function)
- Blood sugar: Fasting glucose, HbA1c (rule out diabetes/prediabetes)
Treat anything that's low or out of range.
3. Hormonal Support
Estrogen therapy:
- Improves energy, sleep, mood
- Supports mitochondrial function
- Many women report energy as one of the first improvements on HT
Progesterone:
- Improves sleep quality (better sleep = more energy)
- Calming effect on nervous system
Combination HT:
- Often most effective for multi-system fatigue
4. Metabolic and Blood Sugar Support
Eat for stable energy:
- Protein at every meal: Stabilizes blood sugar, supports energy
- Healthy fats: Brain and hormone support (avocado, nuts, olive oil, fatty fish)
- Complex carbs: Whole grains, vegetables (not refined carbs/sugar)
- Frequent small meals: Avoid long gaps that cause crashes
- Limit sugar and refined carbs: Cause energy spikes and crashes
Hydration: Dehydration worsens fatigue. Aim for adequate water intake.
5. Movement (Paradoxically)
Gentle, regular movement can improve energy over time (even though it feels impossible when you're exhausted):
- Start very small: 5-10 minute walks
- Don't push to exhaustion: Gentle yoga, stretching, slow walking
- Consistency over intensity: Daily gentle movement beats occasional intense workouts
- Listen to your body: Rest when needed, don't force
Note: If you have post-exertional malaise (PEM) or suspect chronic fatigue syndrome (ME/CFS), consult a specialist before increasing activity.
6. Stress Reduction
Chronic stress + fatigue = worse fatigue:
- Set boundaries: Say no, delegate, let go of non-essentials
- Reduce commitments: This is not forever, but right now you need space
- Therapy or coaching: Support for navigating this phase
- Nervous system regulation: Breathwork, meditation, gentle yoga
- Treat yourself with compassion: You're not lazy; you're managing a major physiological transition
7. Supplements (Discuss with Clinician)
For energy support:
- Iron: If deficient (take with vitamin C for absorption)
- Vitamin B12: If low (sublingual or injections if severely deficient)
- Vitamin D: 1000-2000 IU daily if deficient
- Magnesium: Supports sleep, energy production, stress response (300-400mg)
- CoQ10: Supports mitochondrial function (100-200mg)
- Adaptogenic herbs: Ashwagandha, rhodiola (if appropriate, not for everyone)
Avoid:
- Relying on caffeine (creates crashes, worsens sleep)
- Energy drinks (sugar, stimulants, crashes)
8. Cognitive and Emotional Support
Reframe expectations:
- You're not "failing"—you're navigating a massive biological transition
- Lower the bar temporarily (not forever)
- Prioritize ruthlessly: What truly matters right now?
Grief and validation:
- It's okay to grieve the loss of your former energy
- Your fatigue is real, not imagined or exaggerated
- You're not alone—this is incredibly common
Duration and Recovery
Fatigue typically:
- Begins or worsens in Electric Cougar or Wild Tide
- Peaks during Wild Tide (worst sleep, most hormonal chaos)
- Improves gradually as hormones stabilize in Pause and beyond
- Largely resolves by Phoenix or Golden Sovereignty (with treatment and support)
Many women report energy returning to near-baseline once:
- Sleep improves (hormone therapy, treating night sweats)
- Hormones stabilize (naturally or with HT)
- Underlying issues are treated (thyroid, anemia, etc.)
When It Might Be Something Else
If fatigue is severe, unrelenting, or accompanied by:
- Severe depression or suicidal thoughts
- Unexplained weight loss
- Fever, night sweats (unrelated to hot flashes)
- Swollen lymph nodes
- Post-exertional malaise (crashes for days after minor activity)
- Joint pain and stiffness (autoimmune signs)
Investigate further:
- Depression or other mental health conditions
- Chronic Fatigue Syndrome (ME/CFS)
- Fibromyalgia
- Autoimmune conditions (lupus, rheumatoid arthritis, MS)
- Sleep apnea
- Cancer (rare, but can cause profound fatigue)
The Bottom Line
Crashing fatigue is:
- Common in perimenopause (60-70%)
- Multi-factorial (sleep, hormones, thyroid, anemia, stress)
- Treatable (address underlying causes)
- Often improves dramatically with hormone therapy, sleep restoration, and metabolic support
- Temporary for most women
You don't have to accept exhaustion as your new normal. Investigate, treat, rest, and trust that energy will return.
Phase impact
Minimal. Fatigue is usually situational (poor sleep, stress, illness) and resolves with rest.
First hints appear—more tired than usual, needing more rest, energy feels less reliable.
Peak severity. Profound exhaustion, sleep deprivation, crashes, inability to function at previous level.
Still significant. Cumulative sleep debt and hormonal chaos contribute to ongoing exhaustion.
Fatigue often improves as sleep stabilizes and hormones settle, but may linger if underlying issues aren't addressed.
Most women report significant energy improvement with treatment, sleep restoration, and hormonal stabilization.
Energy typically returns to a new baseline. Some women report needing more rest than in their 30s, but profound fatigue resolves.
Typical vs. concerning
Typical: Profound fatigue linked to poor sleep, hormonal changes, cyclical patterns, improves with rest and treatment. Concerning: Fatigue with unexplained weight loss, fever, swollen lymph nodes, severe depression, post-exertional malaise lasting days, or no improvement despite addressing sleep and hormones.
When it makes sense to get medical input
If fatigue is severe and unrelieved by rest. To test for thyroid dysfunction, anemia, vitamin deficiencies. If fatigue is interfering with work or daily life. If accompanied by depression, weight changes, or other concerning symptoms. To discuss hormone therapy or other treatments.